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(4R)-N-[4-({[2-(dimethylamino)ethyl]amino}carbonyl)-1,3-thiazol-2-yl]-4-methyl-1-oxo-2,3,4,9-tetrahydro-1H-beta-carboline-6-carboxamide

Development stage
Preclinical
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
Administration
Oral, Intravenous (potentially; Not Confirmed Clinically)
01

Overview

This compound is a synthetic small molecule belonging to the beta-carboline class of organic compounds. Beta-carbolines are tricyclic alkaloids structurally related to tryptamine and are known for a variety of pharmacological activities. The specific compound described here features a thiazole ring and dimethylamino substituent. While detailed clinical data on this exact molecule is not available in public sources as of June 2025, beta-carbolines as a class have been studied for their interactions with several biological targets including benzodiazepine receptors (GABA-A receptor modulatory site), serotonin receptors (notably 5‑HT₂A/₂C), monoamine oxidase enzymes (MAO inhibition), and phosphodiesterase type 5 (PDE5). Some beta-carbolines have demonstrated hallucinogenic properties or anxiolytic effects depending on their substitution pattern. This particular compound has been referenced in experimental contexts and may act as an inhibitor of PDE5 based on patent literature describing similar structures[2][5][9].

02

Targets

PDE5 (Phosphodiesterase 5A)BZD site (GABA-A receptor benzodiazepine site)

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